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HMGB1 Antibody, FITC conjugated

ArtNr CSB-PA010553YC01HU-50ug
Hersteller Cusabio
Menge 50ug
Kategorie
Typ Antibody Polyclonal
Format Liquid
Applikationen ELISA
Specific against Human
Host Rabbit
Isotype IgG
Konjugat/Tag FITC
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Amphoterin antibody; Chromosomal protein; nonhistone; HMG1 antibody; DKFZp686A04236 antibody; High mobility group 1 antibody; High mobility group box 1 antibody; High mobility group protein 1 antibody; High mobility group protein B1 antibody; high-mobility group (nonhistone chromosomal) protein 1 antibody; HMG-1 antibody; HMG1 antibody; HMG3 antibody; HMGB 1 antibody; HMGB1 antibody; HMGB1_HUMAN antibody; NONHISTONE CHROMOSOMAL PROTEIN HMG1 antibody; SBP 1 antibody; Sulfoglucuronyl carbohydrate binding protein antibody, High mobility group protein B1 (High mobility group protein 1) (HMG-1), HMGB1, HMG1
Similar products HMGB1, HMG1, High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Lieferbar
Immunogen Species
Human
UniprotID
P09429
Immunogen
Recombinant Human High mobility group protein B1 protein (2-215AA)
Applications info
ELISA
Background
Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance (PubMed:23519706, PubMed:23446148, PubMed:23994764, PubMed:25048472). Has proangiogdenic activity (By similarity). May be involved in platelet activation (By similarity). Binds to phosphatidylserine and phosphatidylethanolamide (By similarity). Bound to RAGE mediates signaling for neuronal outgrowth (By similarity). May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP (PubMed:23303669, PubMed:25549101).
Conjugate
FITC
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage
Upon receipt, store at -20C or -80C. Avoid repeated freeze.
Purification Method
>95%, Protein G purified
General Research Areas
Epigenetics and Nuclear Signaling
Initial Research Areas
Epigenetics and Nuclear Signaling

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50ug
Lieferbar: In stock
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