Long Description (4000 Characters) |
The clone B-A38, a mouse monoclonal antibody, recognizes an 85-92kDa single chain transmembrane proteoglycan known as CD138 or Syndecan-1. CD138 is commonly expressed on pre-B cells, immature B cells, plasma cells, and on some non-hematopoietic cells, including embryonic mesenchymal cells, vascular smooth muscle cells, endothelial and neural cells, on differentiating keratinocytes and in the epidermis of injured tissue. The presence of soluble CD138 (sCD138) in serum is considered as an important prognostic factor of cancerogenesis in some patients. |