ArtNr |
BS91128-100 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, FC, IP, IHC |
Specific against |
Human, Mouse |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
PSMB9, LMP2, PSMB6i, RING12, Beta1i, Large multifunctional peptidase 2, Large multifunctional protease 2, LMP 2, LMP2, Low molecular mass protein 2, Macropain chain 7, MGC70470, Multicatalytic endopeptidase complex chain 7, OTTHUMP00000062982, Proteasome |
Lieferbar |
|
Swiss-Prot |
P28065(Human) P28076(Mouse) |
Application_all |
WB:1:500-1:1, 000 IHC:1:50-1:200 FC:1:50-1:100 |
Background |
The eukaryotic multicatalytic proteinase complex, otherwise known as the proteasome, is present in both the nucleus and cytoplasm of cells and contains at least 15 nonidentical subunits, which form a highly ordered ring-shaped structure. The proteasome is involved in an ATP/Ubiquitin-dependent proteolytic pathway and expresses at least five distinct proteolytic activities, including the cleavage of peptides after branched chain amino acids or bulky hydrophobic amino acids. Two components of the proteasome are the low molecular mass proteins LMP2 and LMP7, which are thought to connect the proteasome to the MHC class-I antigen-processing pathway. Upon stimulation with IFN-gamma, LMP2 and LMP7 displace housekeeping subunits in the proteasome and activate cytotoxic T cells (CTLs). LMP2 and LMP7 are produced as precursor proteins, which are processed to subunits that have the ability to complex with the proteasome. LMP2 is expressed as two alternatively spliced forms, LMP2.l and LMP2.s, in lymphoblastoid cell lines and in fibroblasts after IFN-gamma stimulation. LMP7 is also expressed as two forms, LMP7-E1 and E2, in several tissues. |
Product |
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Purification And Purity |
ProA affinity purified |
Storage And Stability |
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles. |
Specificity |
PSMB9 polyclonal antibody detects endogenous levels of PSMB9 protein. |
BiowMW |
23 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Immunogen |
Recombinant protein |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.