ArtNr |
BS90923-100 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
100ul |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, FC, IF, IHC, ICC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Herpesvirus entry mediator B, HveB, CD112, NECTIN2, HVEB, PRR2, PVRL2, CD 112, CD112, CD112 antigen, Herpes virus entry mediator B, Herpes virus entry protein B, Herpesvirus entry mediator B, Herpesvirus entry protein B, Hve B, HveB, Nectin-2, Nectin2, Po |
Lieferbar |
|
Swiss-Prot |
Q92692(Human) P32507(Mouse) Q5FVC5(Rat) |
Application_all |
WB:1:500-1:2000 ICC:1:50 IHC:1:50-1:200 FC:1:50-1:100 |
Background |
Nectin is a Ca2+-independent homophilic cell adhesion molecule that belongs to the immunoglobulin superfamily. Human nectin is identical to the poliovirus receptor-related protein (PRR) and has been identified as the alpha-herpesvirus entry mediator. Nectin constitutes a family consisting of at least Nectin 1, 2 and 3; each member has two or three splicing variants. Nectin 2, also designated PRR2/HveB, is ubquitously expressed, with the highest levels of expression in some human neuronal cell lines, fibroblastic cells, keratinocytes and primary activated T lymphocytes. Nectin 2 has two splicing variants, Nectin 2alpha (short form) and 2delta (long form). Both Nectin 2alpha and 2delta have a C-terminal conserved motif (E/A-X-Y-V). This motif interacts with the PDZ domain of the F-Actin-binding protein afadin, through which it is linked to the Actin cytoskeleton. The extracellular regions of the splicing variants are identical, but their transmembrane regions and cytoplasmic regions are unique. Nectin 2 mediates the entry of three mutant herpes simplex virus type 1 (HSV-1) strains that do not use HveA as co-receptor, but not wildtype HSV-1 strains. Nectin 2 also mediates the entry of HSV-2 and pseudorabies virus, but not bovine herpes virus type 1. Nectin 2delta is tyrosine phosphorylated in response to cell-cell adhesion. |
Product |
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Purification And Purity |
ProA affinity purified |
Storage And Stability |
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles. |
Specificity |
Nectin 2 polyclonal antibody detects endogenous levels of Nectin 2 protein. |
BiowMW |
58 kDa |
Note |
For research use only, not for use in diagnostic procedure. |
Immunogen |
Recombinant protein within human Nectin 2 aa 50-250. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.