ArtNr |
BS90746-50 |
Hersteller |
Bioworld Technology, Inc
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, IF, IP, IHC, ICC |
Specific against |
Human, Mouse, Rat |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
SGN5, Signalosome subunit 5, COPS5, CSN5, JAB1, 38 kDa Mov34 homolog, COP9 (constitutive photomorphogenic) homolog subunit 5, COP9 constitutive photomorphogenic homolog subunit 5, COP9 signalosome complex subunit 5, COP9 signalosome subunit 5, Cop9 subuni |
Lieferbar |
|
Swiss-Prot |
Q92905(Human) O35864(Mouse) |
Application_all |
WB:1:500 ICC:1:100-1:500 IHC:1:50-1:200 |
Background |
Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. The coactivator of Jun, designated JAB1 (for Jun-activation domain-binding protein), interacts with c-Jun and Jun D, but not with Jun B or v-Jun. This interaction enhances the transactivating ability of Jun proteins by stabilizing their binding to the TRE. The gene encoding JAB1 maps to human chromosome 8q12.3. |
Product |
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
Purification And Purity |
ProA affinity purified |
Storage And Stability |
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles. |
Specificity |
JAB1 polyclonal antibody detects endogenous levels of JAB1 protein. |
BiowMW |
37 kDa, additional band 100 kDa. |
Note |
For research use only, not for use in diagnostic procedure. |
Immunogen |
Recombinant protein |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.