NME3 polyclonal antibody

Q13232

The nm23 protein is implicated in a variety of biological processes, including suppressing metastasis, phytochrome responses in plants and regulating differentiation. Nm23-H1, nm23-H2 and nm23-H2, members of the nm23 family, are putative metastasis suppressor genes that encode nucleoside diphosphate kinase (NDPK) A and B. NDPKs form oligomers, which are distributed in both the soluble and particulate fractions of cells. Upon cAMP-induced differentiation of rat cells, nm23 proteins show a differential interaction with intermediate filaments. Both isoforms also associate with GFAP in differentiated cells. nm23 proteins and their mutants are localized predominantly in the mitochondria. Nm23 mutants are unable to inhibit differentiation and promote apoptosis as a results of defective protein-protein interactions in the mitochondria.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

NME3 polyclonal antibody detects endogenous levels of NME3 protein.

For research use only, not for use in diagnostic procedure.