GPR149 polyclonal antibody

Q15475

The Six proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Six2, Six4 (AREC3) and Six5 bind to the same DNA sequence, indicating that they may regulate the same target genes. Six1 and Sx4 are both capable of transactivating MEF3 site containing reporter genes, such as myogenin. It has been demonstrated that alterations to homeobox-containing genes may result in cancer. Six1 expression has been shown to be absent or low in normal adult tissues, although it is expressed in several tumor types, including breast carcinoma. Six1 overexpression has been shown to abrogate the G2 cell cycle checkpoint.

The protein was purified from E.coli and the purity is > 95% (by SDS-PAGE).

SIX1 polyclonal antibody detects endogenous levels of SIX1 protein.

For research use only, not for use in diagnostic procedure.