ArtNr |
BOS-M00796-3 |
Hersteller |
Boster
|
Menge |
100 ug/vial |
Kategorie |
|
Typ |
Antibody Monoclonal |
Format |
Lyophilized |
Applikationen |
WB |
Clon |
6D6E1 |
Specific against |
Human, Mouse, Rat |
Host |
Mouse |
Isotype |
IgG2b |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Mouse Monoclonal Antibodies |
Short Description |
Boster Bio Anti-SHC Antibody Picoband™ (monoclonal, 6D6E1) catalog # M00796-3. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. |
Description |
Boster Bio Anti-SHC Antibody Picoband™ (monoclonal, 6D6E1) catalog # M00796-3. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. |
Background |
SHC, also known as SHC1 (SHC-transforming protein 1) or SHCA, is a protein that in humans is encoded by the SHC1 gene. SCOP classifies the 3D structure as belonging to the SH2 domain family. This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. |
Gene Name |
SHC1 |
Application Details |
Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat |
Application Notes |
Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. |
Clonality |
Monoclonal |
Concentration |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Contents |
Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4. |
Immunogen |
A synthetic peptide corresponding to a sequence at the C-terminus of human SHC, identical to the related mouse and rat sequences. |
Purification |
Immunogen affinity purified. |
Storage |
At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing. |
Reconstitution |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Molecular Weight |
65 kDa |
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