ELK-1 [pS383]

Serine383 phosphorylated human ETS-like transcription factor 1 (p383 ELK-1)

Reactive to serine383 phosphorylated human ELK-1 peptide fragment conjugated with KLH or the peptide-BSA conjugate. Not reactive to un-conjugated serine383 phosphorylated human ELK-1 peptide, KLH or BSA.

Human, others not tested

ELK1 belongs to the EST transcription factor family. Proteins in the family have a unique DNA binding domain that binds to conserved DNA sequences. Phosphorylation of ELK1 at Serine 383 and 389 by mitogen-activated protein kinases (MAPKs) activates ELK1. The binding of ELK1 to target sequences is also regulated by its co-factor, serum response factor (SRF), by alternative splicing, and by SUMOylation. ELK1 regulates the transcription of c-fos and genes encoding cytoskeleton proteins, and was found to play a role in long-term memory formation, drug addiction and other neurological disorders.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Phosphorylation, metabolism