Hepatitis C Virus (HCV) NS-3

Mouse monoclonal antibody to human hepatitis virus C (HCV) non-structural protein NS-3

Purified recombinant chimeric HCV polyprotein (555 amino acid residues)

Protein G affinity purified

No cross reaction was found with synthetic recombinant core protein C + envelope protein M (residues 1-142 on HCV polyprotein), synthetic core protein C (residues 1 -61), synthetic NS-3 protein (residues 1378-1458) and synthetic NS-4a protein (residues 1689-1735).

Hepatitis C virus (HCV) causes chronic hepatitis and liver cirrhosis in human through blood and body fluid transmission. HCV has a positive sense single RNA genome enclosed in the nucleocapsid made of core protein (capsid protein). The nucleocapsid is covered by an envelope made of lipoproteins (E1 and E2). The 9.6 kb HCV genome has a single open-reading frame, which is to be translated into a single polyprotein. HCV viral proteins are produced after processing the polyprotein. Genes for core protein and envelop proteins are located adjacently at the 5’-end of HCV genome, followed by genes for non-structural proteins including NS2, NS3, NS4A, NS4B, NS5, NS5A and NS5B.

Double distillated water is recommended to adjust the final concentration to 1.00mg/mL.

Virology