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Interleukin-8 (IL-8)

Interleukin-8 (IL-8)

ArtNr	ANOG-MO-C40017G
Hersteller	Anogen
Menge	0.5mg
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Carcinoma Western Blot ELISA Primary Antibodies By Organ Heart & Blood Cancer Neutralization
Typ	Antibody Monoclonal
Format	Aff. Pur
Applikationen	WB, ELISA, NT
Clon	807
Specific against	Human
Host	Mouse
Isotype	IgG1 kappa
Protein Familie	Cytokine, Growth Factors
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Similar products	IL-8
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Description	Mouse monoclonal antibody to human interleukin 8 (IL-8)
Target Protein	Human IL-8
Immunogen	Purified recombinant human IL-8
Specificity	This antibody recognizes both recombinant and native human IL-8.
Purification	Protein G affinity purified
Species Reactivity	Human, other species not tested
Cross Reactivity	This antibody does not cross react with human Monocyte Chemotactic Activating Factor (MCAF) or RANTES (Regulated on Activation, Normal T-cell Expressed, and Secreted).
Myeloma	Sp2/0-Ag14
Background	Interleukin 8 (IL-8), like IL-6, is secreted by macrophages and a variety of cells that express Toll-like receptors in response to the stimulation of pathogens. IL-8's primary function is to recruit neutrophils and other target cells through chemotaxis to the infected site to eliminate pathogens. IL-8 causes increased intracellular Ca2+, release of reactive oxygen species, and other physiological changes required for migration and phagocytosis. IL-8 is also known to promote angiogenesis.
Formulation	Lyophilized from a solution in 0.01M PBS, pH 7.0
Reconstitution	Double distilled water is recommended to adjust the final concentration to 1.00mg/mL
Application info	ELISA: React with human IL-8. Matched pair antibodies are available. Neutralizing: In chemotaxis assay, the antibody inhibited 95.1% of the chemotactic activity of IL-8 on RB/293 cell. 50ug/mL of antibody and 10ng/ml of human IL-8 were used in assay. This antibody inhibited the chemotactic effect of human IL-8, had no inhibitory effect to MIP 1-bata and RANTES in neutrophil chemotaxis assay, indicating the neutralizing activity is specific. The antibody also neutralized IL-8 induced calcium influx in human granulocytes. Western Blot: The antibody when used at concentration of 0.02-0.1 ug/ml will allow visualization of 100ng/lane of human IL-8.
Research Area	Cytokine, interleukin and chemotaxis
Storage	Store at -20C

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