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Interleukin-8 (IL-8)

Interleukin-8 (IL-8)

ArtNr	ANOG-MO-C40017A
Hersteller	Anogen
Menge	0.5mg
Kategorie	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Carcinoma Western Blot ELISA Primary Antibodies By Organ Heart & Blood Cancer Neutralization
Typ	Antibody Monoclonal
Format	Aff. Pur
Applikationen	WB, ELISA, NT
Clon	I8-S2
Specific against	Human
Host	Mouse
Isotype	IgG2b kappa
Protein Familie	Cytokine, Growth Factors
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Similar products	IL-8
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Description	Mouse monoclonal antibody to human interleukin 8 (IL-8)
Target Protein	Human IL-8
Immunogen	Purified recombinant human IL-8
Specificity	This antibody recognizes both recombinant and native human IL-8.
Purification	Protein G affinity purified
Species Reactivity	Human, other species not tested
Cross Reactivity	This antibody does not cross react with human Monocyte Chemotactic Activating Factor (MCAF) or RANTES (Regulated on Activation, Normal T-cell Expressed, and Secreted).
Myeloma	Sp2/0-Ag14
Background	Interleukin 8 (IL-8), like IL-6, is secreted by macrophages and a variety of cells that express Toll-like receptors in response to the stimulation of pathogens. IL-8's primary function is to recruit neutrophils and other target cells through chemotaxis to the infected site to eliminate pathogens. IL-8 causes increased intracellular Ca2+, release of reactive oxygen species, and other physiological changes required for migration and phagocytosis. IL-8 is also known to promote angiogenesis.
Formulation	Lyophilized from a solution in 0.01M PBS, pH 7.0
Reconstitution	Double distilled water is recommended to adjust the final concentration to 1.00mg/mL
Application info	ELISA: The antibody matches with clone I8-60 (Cat. No: MO-C40017D) in sandwich ELISA. Neutralization: In chemotaxis assay, the antibody inhibited 97.8% % of the chemotactic activity of IL-8 on RB/293 cell. 5ug/mL of antibody and 10ng/mL of human IL-8 were used in the assay. This antibody inhibited the chemotactic effect of human IL-8, but had no inhibitory effect to MIP 1-bata and RANTES in neutrophil chemotaxis assay. The antibody also neutralized IL-8 induced calcium influx in human granulocytes. Western Blot: The antibody, when used at concentration of 0.02-0.1?g/mL antibody will allow visualization of 100ng/lane of recombinant human IL-8.
Research Area	Cytokine, interleukin and chemotaxis
Storage	Store at -20C

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