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TYSY Antibody(C-term)

TYSY Antibody(C-term)

ArtNr	ABC-AX10003-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, FC, IF, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TYMS, Thymidylate synthase, TS, TSase
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Primary Accession	P04818
Antigen Type	Synthetic Peptide
Application	FC, IF, IHC-P, WB
Bio Background	Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.
Bio References	Ren, D.N., J Surg Oncol (2009) Schiffer, C.A., Biochemistry 34 (50), 16279-16287 (1995)
Clonality	Polyclonal
Clone/Animal Names	RB20041
Gene ID	7298
Gene Name	TYMS
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Confocal immunofluorescent analysis of TYSY Antibody (C-term) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
Type image 1	IF
Dilution image 1	1:50
Legend image 2	Confocal immunofluorescent analysis of TYSY Antibody (C-term) with WiDr cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
Type image 2	IF
Dilution image 2	1:50
Legend image 3	TYSY Antibody (C-term) (Cat. #AX10003) western blot analysis in Hela, Jurkat and HL-60 cell line lysates (35ug/lane).This demonstrates the TYSY antibody detected the TYSY protein (arrow).
Type image 3	WB
Dilution image 3	1:2000
Legend image 4	TYSY Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TYSY Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 4	IHC-P
Dilution image 4	1:500
Legend image 5	TYSY Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TYSY Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 5	IHC-P
Dilution image 5	1:500
Legend image 6	TYSY Antibody (C-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 6	FC
Dilution image 6	1:50
Isotype	Rabbit Ig
Calculated MW	35716
Antigen Region	265-294
Antigen Source	HUMAN
Target/Specificity	This TYSY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human TYSY.
NCBI Accession	NP_001062.1

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Menge: 80 ul

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