ArtNr |
ABC-AW5517-U100 |
Hersteller |
Abcepta
|
Menge |
100 ul |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
ACAT1, mitochondrial, MAT, ACAT, T2, Acetyl-CoA acetyltransferase, Acetoacetyl-CoA thiolase |
Lieferbar |
|
Primary Accession |
P24752 |
Antigen Type |
Synthetic Peptide |
Application |
IHC-P, WB |
Bio Background |
ACAT1 is a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in the gene encoding ACAT1 are associated with the alpha-methylacetoaceticaciduria disorder, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. |
Bio References |
Locke, J.A., Prostate 68 (1), 20-33 (2008)Guo, Z.Y., Biochemistry 46 (35), 10063-10071 (2007)Haapalainen, A.M., Biochemistry 46 (14), 4305-4321 (2007) |
Clonality |
Polyclonal |
Gene ID |
38 |
Gene Name |
ACAT1 |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, M |
Legend image 1 |
All lanes : Anti-ACAT1 Antibody (C-term) at 1:1000 dilutionLane 1: HepG2 whole cell lysatesLane 2: mouse liver lysatesLane 3: SK-BR-3 whole cell lysatesLane 4: SW620 whole cell lysatesLysates/proteins at 20 µg per lane. SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 45 kDaBlocking/Dilution buffer: 5% NFDM/TBST. |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with ACAT1 antibody (C-term) (Cat.#AW5517), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Type image 2 |
IHC-P |
Dilution image 2 |
1:10~50 |
Isotype |
Rabbit Ig |
Calculated MW |
45200 |
Antigen Region |
311-349 |
Antigen Source |
HUMAN |
Target/Specificity |
This ACAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-349 amino acids from the C-terminal region of human ACAT1. |
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