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EGFR Antibody (C-term)

EGFR Antibody (C-term)

ArtNr	ABC-AW5388-U100
Hersteller	Abcepta
Menge	100 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	EGFR, ERBB, ERBB1, HER1, Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
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Primary Accession	P00533
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Bio References	Abdallah, R.T., et al. J. Biol. Chem. 285(45):35206-35215(2010) Lu, C., et al. Mol. Cell. Biol. 30(22):5432-5443(2010) Rosell, R., et al. Ann. N. Y. Acad. Sci. 1210, 45-52 (2010) : Hata, A., et al. J Thorac Oncol 5(10):1524-1528(2010) Aguirre, A., et al. Nature 467(7313):323-327(2010)
Clonality	Monoclonal
Gene ID	1956
Gene Name	EGFR (HGNC:3236)
Subtitle	Mouse Monoclonal Antibody (Mab)
Reactivity	H
Legend image 1	All lanes : Anti-EGFR Antibody (C-term) at 1:1000 dilution Lane 1: A431 whole cell lysates Lane 2: Hela whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 134 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Immunohistochemical analysis of paraffin-embedded R. esophagus section using EGFR Antibody (C-term)(Cat#AW5388). AW5388 was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-mouse IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
Type image 2	IHC-P
Dilution image 2	1:25
Legend image 3	Immunohistochemical analysis of paraffin-embedded M. esophagus section using EGFR Antibody (C-term)(Cat#AW5388). AW5388 was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-mouse IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
Type image 3	IHC-P
Dilution image 3	1:25
Legend image 4	Immunohistochemical analysis of paraffin-embedded H. stomach section using EGFR Antibody (C-term)(Cat#AW5388). AW5388 was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-mouse IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
Type image 4	IHC-P
Dilution image 4	1:25
Legend image 5	Immunohistochemical analysis of paraffin-embedded H. esophagus section using EGFR Antibody (C-term)(Cat#AW5388). AW5388 was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-mouse IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
Type image 5	IHC-P
Dilution image 5	1:25
Other Accession	NP_005219.2
Isotype	IgG1
Calculated MW	134277
Antigen Region	1163-1191
Antigen Source	HUMAN
Target/Specificity	This EGFR antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 1163-1191 amino acids from the C-terminal region of human EGFR.
NCBI Accession	NP_005219.2; NP_958439.1; NP_958440.1; NP_958441.1

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Menge: 100 ul

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