ArtNr |
ABC-AW5318-U100 |
Hersteller |
Abcepta
|
Menge |
100 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
Gemin-2, SIP1, GEMIN2, SMN-interacting protein 1, Component of gems 2, Gem-associated protein 2, Survival of motor neuron protein-interacting protein 1 |
Lieferbar |
|
Primary Accession |
O14893 |
Antigen Type |
Synthetic Peptide |
Application |
WB |
Bio Background |
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. |
Bio References |
Liu Q., et al.Cell 90:1013-1021(1997).Aerbajinai W., et al.Int. J. Biochem. Cell Biol. 34:699-707(2002).Helmken C., et al.Eur. J. Hum. Genet. 8:493-499(2000).Ota T., et al.Nat. Genet. 36:40-45(2004).Gubitz A.K., et al.J. Biol. Chem. 277:5631-5636(2002). |
Clonality |
polyclonal |
Gene ID |
8487 |
Gene Name |
GEMIN2 |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Western blot analysis of lysates from Hela, K562, MCF-7 cell line (from left to right), using SIP1 Antibody (C-term)(Cat. #AW5318). AW5318 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane. |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Predicted |
M, Rat |
Isotype |
Rabbit Ig |
Calculated MW |
31585 |
Antigen Region |
244-277 |
Antigen Source |
HUMAN |
Target/Specificity |
This SIP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 244-277 amino acids from the C-terminal region of human SIP1. |
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