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USP15 Antibody (monoclonal) (M01)

USP15 Antibody (monoclonal) (M01)

ArtNr	ABC-AT4484a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IF
Clon	1C10
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	USP15, KIAA0529, Ubiquitin carboxyl-terminal hydrolase 15, Deubiquitinating enzyme 15, Ubiquitin thioesterase 15, Ubiquitin-specific-processing protease 15, Unph-2, Unph4
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Primary Accession	Q9Y4E8
Antigen Type	Recombinant Protein
Application	WB, IF
Bio Background	Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).
Bio References	1.The Ubiquitin-Specific Protease USP15 Promotes RIG-I–Mediated Antiviral Signaling by Deubiquitylating TRIM25.Pauli EK, Chan YK, Davis ME, Gableske S, Wang MK, Feister KF, Gack MU.Science Signaling 7 (307), ra3.2.The Ubiquitin-Specific Protease USP15 Promotes RIG-I-Mediated Antiviral Signaling by Deubiquitylating TRIM25.Pauli EK, Chan YK, Davis ME, Gableske S, Wang MK, Feister KF, Gack MUSci Signal. 2014 Jan 7; 7(307):ra3. doi: 10.1126/scisignal.2004577.3.The Human COP9 Signalosome Protects Ubiquitin-conjugating Enzyme 3 (UBC3/Cdc34) from {beta}-Transducin Repeat-containing Protein ({beta}TrCP)-mediated Degradation.Fernandez-Sanchez ME, Sechet E, Margottin-Goguet F, Rogge L, Bianchi E.J Biol Chem. 2010 Jun 4; 285(23):17390-7. Epub 2010 Apr 8.4.COP9 Signalosome Interacts ATP-dependently with p97/Valosin-containing Protein (VCP) and Controls the Ubiquitination Status of Proteins Bound to p97/VCP.Cayli S, Klug J, Chapiro J, Frohlich S, Krasteva G, Orel L, Meinhardt A.J Biol Chem. 2009 Dec 11; 284(50):34944-53. Epub 2009 Oct 13.5.USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis.Xu M, Takanashi M, Oikawa K, Tanaka M, Nishi H, Isaka K, Kudo M, Kuroda M.Biochem Biophys Res Commun. 2009 Oct 16; 388(2):366-71. Epub 2009 Aug 8.6.The Ubiquitin Specific Peptidase USP15 Regulates Human Papilloma Virus 16 E6 Protein Stability.Vos RM, Altreuter J, White EA, Howley PM.J Virol. 2009 Sep; 83(17):8885-92. Epub 2009 Jun 24.7.The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible factor-alpha ubiquitination.Miyauchi Y, Kato M, Tokunaga F, Iwai K.J Biol Chem. 2008 Jun 13; 283(24):16622-16631. Epub 2008 Apr 18.8.CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha.Schweitzer K, Bozko PM, Dubiel W, Naumann M.EMBO J. 2007 Mar 21; 26(6):1532-41. Epub 2007 Feb 22.
Clonality	Monoclonal
Gene ID	9958
Gene Name	USP15 {ECO:0000303\|PubMed:10444327, ECO:0000312\|HGNC:HGNC:12613}
Subtitle	Mouse monoclonal antibody raised against a full length recombinant USP15.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to USP15 on HeLa cell. [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (51.59 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	USP15 monoclonal antibody (M01), clone 1C10 Western Blot analysis of USP15 expression in HepG2 ( (Cat # AT4484a )
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	Western Blot analysis of USP15 expression in transfected 293T cell line by USP15 monoclonal antibody (M01), clone 1C10. Lane 1: USP15 transfected lysate (Predicted MW: 109.3 KDa). Lane 2: Non-transfected lysate.
Type image 4	WB
Dilution image 4	1:500~1000
Other Accession	BC020688
Isotype	IgG1 kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	USP15 (AAH20688, 1 a.a. ~ 235 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001239007.1; NP_001239008.1; NP_006304.1
	Clone: 1C10
Org Accession	AAH20688
Gene Description	ubiquitin specific peptidase 15
Gene Summary	Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM

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Menge: 100 ug

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Lieferung vsl. bis 08.11.2024

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