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UNC119 Antibody (monoclonal) (M01)

UNC119 Antibody (monoclonal) (M01)

ArtNr	ABC-AT4469a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IP
Clon	2F9-2A9
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	UNC119, Protein unc-119 homolog A, Retinal protein 4, hRG4, RG4
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Primary Accession	Q13432
Antigen Type	Recombinant Protein
Application	WB, IP
Bio Background	This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.
Bio References	Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma. Gorska MM, et al. J Immunol, 2010 Apr 15. PMID 20220094.UNC119 inhibits dynamin and dynamin-dependent endocytic processes. Karim Z, et al. Cell Signal, 2010 Jan. PMID 19781630.Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation. Gorska MM, et al. J Immunol, 2009 Aug 1. PMID 19592652.Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. Vepachedu R, et al. J Immunol, 2007 Jul 1. PMID 17579091.Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674.
Clonality	Monoclonal
Gene ID	9094
Gene Name	UNC119
Subtitle	Mouse monoclonal antibody raised against a full length recombinant UNC119.
Reactivity	H
Legend image 1	Immunoprecipitation of UNC119 transfected lysate using anti-UNC119 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with UNC119 purified MaxPab rabbit polyclonal antibody.
Type image 1	IP
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (52.14 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Western Blot analysis of UNC119 expression in transfected 293T cell line by UNC119 monoclonal antibody (M01), clone 2F9-2A9. Lane 1: UNC119 transfected lysate(27 KDa). Lane 2: Non-transfected lysate.
Type image 3	WB
Dilution image 3	1:500~1000
Other Accession	BC027176
Isotype	IgG1 kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	UNC119 (AAH27176.1, 1 a.a. ~ 240 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_005139.1; NP_473376.1
	Clone: 2F9-2A9
Org Accession	AAH27176.1
Concentration	1 mg/ml
Gene Description	unc-119 homolog (C. elegans)
Gene Summary	This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq

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Menge: 100 ug

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