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STIP1 Antibody (monoclonal) (M11)

STIP1 Antibody (monoclonal) (M11)

ArtNr	ABC-AT4077a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IF, IHC, ELISA
Clon	1000
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	STIP1, STI1, Hop, Hsc70/Hsp90-organizing protein, Renal carcinoma antigen NY-REN-11, Stress-induced-phosphoprotein 1, Transformation-sensitive protein IEF SSP 3521
Lieferbar
Primary Accession	P31948
Antigen Type	Recombinant Protein
Application	WB, IHC, IF, E
Bio Background	STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).
Bio References	1.Glaucoma-associated WDR36 variants encode functional defects in a yeast model system.Footz TK, Johnson JL, Dubois S, Boivin N, Raymond V, Walter MA.Hum Mol Genet. 2009 Apr 1; 18(7):1276-87. Epub 2009 Jan 15.
Clonality	Monoclonal
Gene ID	10963
Gene Name	STIP1 (HGNC:11387)
Subtitle	Mouse monoclonal antibody raised against a partial recombinant STIP1.
Reactivity	H, M, Rat
Legend image 1	Immunofluorescence of monoclonal antibody to STIP1 on HeLa cell. [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	STIP1 monoclonal antibody (M11), clone 1E3 Western Blot analysis of STIP1 expression in HeLa ( (Cat # AT4077a )
Type image 3	WB
Dilution image 3	1:500~1000
Legend image 4	STIP1 monoclonal antibody (M11), clone 1E3. Western Blot analysis of STIP1 expression in PC-12 ( (Cat # AT4077a )
Type image 4	WB
Dilution image 4	1:500~1000
Legend image 5	STIP1 monoclonal antibody (M11), clone 1E3. Western Blot analysis of STIP1 expression in Raw 264.7 ( (Cat # AT4077a )
Type image 5	WB
Dilution image 5	1:500~1000
Legend image 6	STIP1 monoclonal antibody (M11), clone 1E3. Western Blot analysis of STIP1 expression in NIH/3T3 ( (Cat # AT4077a )
Type image 6	WB
Dilution image 6	1:500~1000
Legend image 7	Immunoperoxidase of monoclonal antibody to STIP1 on formalin-fixed paraffin-embedded human lung. [antibody concentration 3 ug/ml]
Type image 7	IHC
Other Accession	NM_006819
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	STIP1 (NP_006810.1, 445 a.a. ~ 543 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_006810.1
	Clone: 1000
Legend image 8	Detection limit for recombinant GST tagged STIP1 is approximately 0.03ng/ml as a capture antibody.
Org Accession	NP_006810.1
Concentration	0.782mg/ml
Gene Description	stress-induced-phosphoprotein 1
Gene Summary	STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM

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Menge: 100 ug

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