SIRT1 Antibody (monoclonal) (M03)

Q96EB6

WB, E

SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Fan W, et al. Mol Cell, 2010 Jul 30. PMID 20670893.SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus. Satoh A, et al. J Neurosci, 2010 Jul 28. PMID 20668205.SIRT1 variants are associated with aging in a healthy Han Chinese population. Zhang WG, et al. Clin Chim Acta, 2010 Nov 11. PMID 20633545.Sirtuin 1 regulation of developmental genes during differentiation of stem cells. Calvanese V, et al. Proc Natl Acad Sci U S A, 2010 Aug 3. PMID 20631301.MicroRNA-34a regulation of endothelial senescence. Ito T, et al. Biochem Biophys Res Commun, 2010 Aug 6. PMID 20627091.

23411

Mouse monoclonal antibody raised against a partial recombinant SIRT1.

Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .

1:500~1000

WB

Detection limit for recombinant GST tagged SIRT1 is 0.1 ng/ml as a capture antibody.

BC012499

Human: ~~ Positive

NP_001135970.1; NP_036370.2

AAH12499

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq