ArtNr |
ABC-AT3761a |
Hersteller |
Abcepta
|
Menge |
100 ug |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Applikationen |
WB, IF, ELISA |
Clon |
1A4 |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
S100A7, PSOR1, S100A7C, Protein S100-A7, Psoriasin, S100 calcium-binding protein A7 |
Lieferbar |
|
Primary Accession |
P31151 |
Antigen Type |
Recombinant Protein |
Application |
WB, IF, E |
Bio Background |
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known. |
Bio References |
Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility hot-spot. Johnatty SE, et al. PLoS Genet, 2010 Jul 8. PMID 20628624.Evidence for diminished levels of epithelial psoriasin and calprotectin in chronic rhinosinusitis. Tieu DD, et al. J Allergy Clin Immunol, 2010 Mar. PMID 20226301.S100A7 (psoriasin) is induced by the proinflammatory cytokines oncostatin-M and interleukin-6 in human breast cancer. West NR, et al. Oncogene, 2010 Apr 8. PMID 20101226.Structural and functional characterization of a triple mutant form of S100A7 defective for Jab1 binding. West NR, et al. Protein Sci, 2009 Dec. PMID 19844956.Identification and characterization of binding sites on S100A7, a participant in cancer and inflammation pathways. Le?n R, et al. Biochemistry, 2009 Nov 10. PMID 19810752. |
Clonality |
Monoclonal |
Gene ID |
6278 |
Gene Name |
S100A7 |
Subtitle |
Mouse monoclonal antibody raised against a full-length recombinant S100A7. |
Reactivity |
H |
Legend image 1 |
Immunofluorescence of monoclonal antibody to S100A7 on A-431 cell. [antibody concentration 10 ug/ml] |
Type image 1 |
IF |
Legend image 2 |
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.85 KDa) . |
Type image 2 |
WB |
Dilution image 2 |
1:500~1000 |
Legend image 3 |
S100A7 monoclonal antibody (M02), clone 1A4 Western Blot analysis of S100A7 expression in A-431 ( (Cat # AT3761a ) |
Type image 3 |
WB |
Dilution image 3 |
1:500~1000 |
Legend image 4 |
Western Blot analysis of S100A7 expression in transfected 293T cell line by S100A7 monoclonal antibody (M02), clone 1A4.
Lane 1: S100A7 transfected lysate(11.457 KDa). Lane 2: Non-transfected lysate. |
Type image 4 |
WB |
Dilution image 4 |
1:500~1000 |
Legend image 5 |
Detection limit for recombinant GST tagged S100A7 is approximately 10ng/ml as a capture antibody. |
Type image 5 |
E |
Other Accession |
BC034687.1 |
Isotype |
IgG1 Kappa |
Target/Specificity |
S100A7 (AAH34687.1, 1 a.a. ~ 101 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
NCBI Accession |
NP_002954.2 |
|
Clone: 1A4 |
Org Accession |
AAH34687.1 |
Concentration |
1 mg/ml |
Gene Description |
S100 calcium binding protein A7 |
Gene Summary |
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known. [provided by RefSeq |
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