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RIN2 Antibody (monoclonal) (M04)

RIN2 Antibody (monoclonal) (M04)

ArtNr	ABC-AT3643a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, ELISA
Clon	1000000
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	RASSF4, Ras association domain family 4, RIN2, Ras and Rab interactor 2, Ras inhibitor JC265, Ras interaction/interference protein 2
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Primary Accession	Q8WYP3
Antigen Type	Recombinant Protein
Application	WB, E
Bio Background	The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family.
Bio References	The RIN2 syndrome: a new autosomal recessive connective tissue disorder caused by deficiency of Ras and Rab interactor 2 (RIN2). Syx D, et al. Hum Genet, 2010 Jul. PMID 20424861.RIN2 deficiency results in macrocephaly, alopecia, cutis laxa, and scoliosis: MACS syndrome. Basel-Vanagaite L, et al. Am J Hum Genet, 2009 Aug. PMID 19631308.Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin. Kimura T, et al. J Biol Chem, 2006 Apr 14. PMID 16423831.Complete sequencing and characterization of 21, 243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. Kajiho H, et al. J Cell Sci, 2003 Oct 15. PMID 12972505.
Clonality	Monoclonal
Gene ID	54453
Gene Name	RIN2
Subtitle	Mouse monoclonal antibody raised against a partial recombinant RIN2.
Reactivity	H
Legend image 1	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.73 KDa) .
Type image 1	WB
Dilution image 1	1:500~1000
Legend image 2	RIN2 monoclonal antibody (M04), clone 1E6. Western Blot analysis of RIN2 expression in Y-79 ( (Cat # AT3643a )
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Detection limit for recombinant GST tagged RIN2 is 3 ng/ml as a capture antibody.
Type image 3	E
Other Accession	NM_018993
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	RIN2 (NP_061866, 786 a.a. ~ 894 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001229510.1; NP_061866.1
	Clone: 1000000
Org Accession	NP_061866
Concentration	1 mg/ml
Gene Description	Ras and Rab interactor 2
Gene Summary	The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. [provided by RefSeq

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Menge: 100 ug

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