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PSCD1 Antibody (monoclonal) (M01)

PSCD1 Antibody (monoclonal) (M01)

ArtNr	ABC-AT3449a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IF, IHC, ELISA
Clon	1D6
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PH, CYTH1, D17S811E, PSCD1, Cytohesin-1, SEC7 and coiled-coil domain-containing protein 1, SEC7 homolog B2-1
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Primary Accession	Q15438
Antigen Type	Recombinant Protein
Application	WB, IHC, IF, E
Bio Background	The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2.
Bio References	Cytohesin-1 regulates the Arf6-phospholipase D signaling axis in human neutrophils: impact on superoxide anion production and secretion. El Azreq MA, et al. J Immunol, 2010 Jan 15. PMID 20018626.Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells. Quast T, et al. Blood, 2009 Jun 4. PMID 19346499.Cytoskeletal protein radixin activates integrin alpha(M)beta(2) by binding to its cytoplasmic tail. Tang P, et al. FEBS Lett, 2007 Mar 20. PMID 17321526.Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1. Sendide K, et al. J Immunol, 2005 Apr 1. PMID 15778383.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
Clonality	Monoclonal
Gene ID	9267
Gene Name	CYTH1 (HGNC:9501)
Subtitle	Mouse monoclonal antibody raised against a full length recombinant PSCD1.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to PSCD1 on HeLa cell . [antibody concentration 10 ug/ml]
Type image 1	IF
Legend image 2	Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (69.52 KDa) .
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Immunoperoxidase of monoclonal antibody to PSCD1 on formalin-fixed paraffin-embedded human spleen. [antibody concentration 3 ug/ml]
Type image 3	IHC
Legend image 4	Detection limit for recombinant GST tagged PSCD1 is approximately 1ng/ml as a capture antibody.
Type image 4	E
Other Accession	BC050452
Isotype	IgG1 kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	PSCD1 (AAH50452, 1 a.a. ~ 398 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_004753.1; NP_059430.2
	Clone: 1D6
Org Accession	AAH50452
Gene Description	cytohesin 1
Gene Summary	The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. The encoded protein is 83% homologous to that of CYTH2. [provided by RefSeq

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