ArtNr |
ABC-AT3010a |
Hersteller |
Abcepta
|
Menge |
100 ug |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Applikationen |
WB, ELISA |
Clon |
200000000 |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
NF-H, NEFH, Neurofilament heavy polypeptide, Neurofilament triplet H protein, 200 kDa neurofilament protein, KIAA0845, NFH |
Lieferbar |
|
Primary Accession |
P12036 |
Antigen Type |
Recombinant Protein |
Application |
WB, E |
Bio Background |
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. |
Bio References |
A genome-wide association study of carotid atherosclerosis in HIV-infected men. Shrestha S, et al. AIDS, 2010 Feb 20. PMID 20009918.Comparative study of CSF neurofilaments in HTLV-1-associated myelopathy/tropical spastic paraparesis and other neurological disorders. Alberti C, et al. AIDS Res Hum Retroviruses, 2009 Aug. PMID 19678766.Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON). Guy J, et al. Mol Vis, 2008. PMID 19104679.Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence. Greg?rio SP, et al. Psychiatry Res, 2009 Jan 30. PMID 19054571.Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein. Rudrabhatla P, et al. J Biol Chem, 2008 Sep 26. PMID 18635547. |
Clonality |
Monoclonal |
Gene ID |
4744 |
Gene Name |
NEFH |
Subtitle |
Mouse monoclonal antibody raised against a partial recombinant NEFH. |
Reactivity |
H |
Legend image 1 |
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.85 KDa) . |
Type image 1 |
WB |
Dilution image 1 |
1:500~1000 |
Legend image 2 |
NEFH monoclonal antibody (M01), clone 2E8 Western Blot analysis of NEFH expression in HeLa ( (Cat # AT3010a ) |
Type image 2 |
WB |
Dilution image 2 |
1:500~1000 |
Legend image 3 |
Detection limit for recombinant GST tagged NEFH is approximately 0.03ng/ml as a capture antibody. |
Type image 3 |
E |
Other Accession |
NM_021076 |
Isotype |
IgG2a Kappa |
Antigen Source |
Human: ~~ Positive |
Target/Specificity |
NEFH (NP_066554, 263 a.a. ~ 363 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
NCBI Accession |
NP_066554.2 |
|
Clone: 200000000 |
Org Accession |
NP_066554 |
Gene Description |
neurofilament, heavy polypeptide |
Gene Summary |
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq |
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