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DMTF1 Antibody (monoclonal) (M03)

DMTF1 Antibody (monoclonal) (M03)

ArtNr	ABC-AT1784a
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Applikationen	WB, IF, IHC
Clon	5C6
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	DMP1, DMTF1, Cyclin-D-binding Myb-like transcription factor 1, Cyclin-D-interacting Myb-like protein 1, hDMP1, hDMTF1
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Primary Accession	Q9Y222
Antigen Type	Recombinant Protein
Application	WB, IHC, IF
Bio Background	This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Bio References	Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Liu Y, et al. Mol Psychiatry, 2010 Mar 30. PMID 20351715.Role of DMP1 and its future in lung cancer diagnostics. Sugiyama T, et al. Expert Rev Mol Diagn, 2008 Jul. PMID 18598225.Emerging roles of DMP1 in lung cancer. Inoue K, et al. Cancer Res, 2008 Jun 15. PMID 18559489.The hDMP1 tumor suppressor is a new WT1 target in myeloid leukemias. Tschan MP, et al. Leukemia, 2008 May. PMID 17972942.Mutually exclusive inactivation of DMP1 and ARF/p53 in lung cancer. Mallakin A, et al. Cancer Cell, 2007 Oct. PMID 17936562.
Clonality	Monoclonal
Gene ID	9988
Gene Name	DMTF1
Subtitle	Mouse monoclonal antibody raised against a partial recombinant DMTF1.
Reactivity	H
Legend image 1	Immunofluorescence of monoclonal antibody to DMTF1 on HeLa cell. [antibody concentration 30 ug/ml]
Type image 1	IF
Legend image 2	DMTF1 monoclonal antibody (M03), clone 5C6 Western Blot analysis of DMTF1 expression in Hela S3 NE ( Cat # L013V3 ).
Type image 2	WB
Dilution image 2	1:500~1000
Legend image 3	Immunoperoxidase of monoclonal antibody to DMTF1 on formalin-fixed paraffin-embedded human colon. [antibody concentration 1 ug/ml]
Type image 3	IHC
Other Accession	NM_021145
Isotype	IgG2a Kappa
Antigen Source	Human: ~~ Positive
Target/Specificity	DMTF1 (NP_066968, 661 a.a. ~ 760 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
NCBI Accession	NP_001135798.1; NP_001135799.1; NP_066968.3
	Clone: 5C6
Org Accession	NP_066968
Gene Description	cyclin D binding myb-like transcription factor 1
Gene Summary	This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

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Menge: 100 ug

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