C20orf31 Antibody (monoclonal) (M01)

Q9BV94

WB, IHC, IP, E

Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study. Tang W, et al. Blood, 2010 Aug 27. PMID 20802025.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation. Olivari S, et al. J Biol Chem, 2005 Jan 28. PMID 15579471.Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. Mast SW, et al. Glycobiology, 2005 Apr. PMID 15537790.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

55741

Mouse monoclonal antibody raised against a partial recombinant C20orf31.

Immunoprecipitation of EDEM2 transfected lysate using anti-EDEM2 monoclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with EDEM2 MaxPab rabbit polyclonal antibody.

Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .

1:500~1000

WB

Immunoperoxidase of monoclonal antibody to C20orf31 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 1.5 ug/ml]

Detection limit for recombinant GST tagged EDEM2 is 0.1 ng/ml as a capture antibody.

NM_018217

Human: ~~ Positive

NP_001138497.1; NP_060687.2

NP_060687

In the endoplasmic reticulum (ER), misfolded proteins are retrotranslocated to the cytosol and degraded by the proteasome in a process known as ER-associated degradation (ERAD). EDEM2 belongs to a family of proteins involved in ERAD of glycoproteins (Mast et al., 2005 [PubMed 15537790]).[supplied by OMIM