ArtNr |
ABC-ASC12122 |
Hersteller |
Abcepta
|
Menge |
0.1 mg |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, IF, IHC, ICC, ELISA |
Clon |
VSIR |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
C10orf54, GI24, PP2135, SISP1, B7-H5, VISTA, B7H5, DD1alpha, PD-1H, V-set immunoregulatory receptor, VSIR, VISTA Antibody: VISTA molecule, chromosome 10 open reading frame 54, V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation, Chromosome 10 Open Reading Frame 54 |
Lieferbar |
|
Primary Accession |
Q9H7M9 |
Application |
WB, IHC, IF, ICC, E |
Bio Background |
The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5). |
Bio References |
Mayya V., et al . Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. 2009, Sci. Signal. 2:RA46-RA46.Sakr M.A., et al., GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase. 2010, Cancer Sci. 101:2368-2374. |
Clonality |
Polyclonal |
Gene ID |
64115 |
Gene Name |
|
Other Accession |
NP_071436 |
Isotype |
IgG |
Calculated MW |
33908 |
|
Clone: VSIR |
Purification |
VISTA Antibody is affinity chromatography purified via peptide column. |
Reconstitution & Storage |
VISTA antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Positive Control |
Cat. No. 11-533 - Human Tonsil Tissue Slide; |
Buffer |
VISTA Antibody is supplied in PBS containing 0.02% sodium azide. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.