SHROOM1 Antibody

Q2M3G4

SHROOM1 Antibody: SHROOM family members play diverse roles in the development of the nervous system and other tissues. SHROOM1 is a PDZ domain-containing actin-binding protein that is required for neural tube morphogenesis. It facilitates neurulation by regulating the morphology of neurepithelial cells via the apical positioning of an actomyosin network in the neurepithelium. SHROOM1 is also expressed in pulmonary arterial smooth muscle cells and its expression is significantly decreased in mouse and human models of pulmonary arterial hypertension, suggesting that there may be a link between SHROOM1 expression and pulmonary arterial hypertension.

Polyclonal

SHROOM1

Western blot analysis of SHROOM1 in mouse heart tissue lysate with SHROOM1 antibody at 1 µg/mL in (A) the absence and (B) the presence of blocking peptide.

NP_001166171; 289577098

90786

SHROOM1; SHROOM1 antibody is human, mouse and rat reactive. At least three isoforms of SHROOM1 are known to exist; this antibody will detect only the two largest isoforms. SHROOM1 antibody is predicted to not cross-react with other SHROOM family members.

SHROOM1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

SHROOM1 antibody can be used for detection of SHROOM1 by Western blot at 1 - 2 µg/mL.

SHROOM1 Antibody is supplied in PBS containing 0.02% sodium azide.