APBA1 Antibody

Q02410

APBA1 Antibody: The Amyloid beta 4 (A4) precursor protein-binding family A member 1 (APBA1) is a member of the X11 protein family and a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). APBA1 stabilizes APP and inhibits production of proteolytic APP fragments including the Aβ peptide that is deposited in the brains of Alzheimer's disease patients. It is thought to be involved in signal transduction processes and is a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. APBA1 can also bind to CASK, a multidomain scaffolding protein involved in brain development and synapse formation.

Polyclonal

APBA1

Western blot analysis of APBA1 in rat brain tissue lysate with APBA1 antibody at 0.5 µg/ml in (A) the absence and (B) the presence of blocking peptide.

Immunofluorescence of APBA1 in human brain tissue with APBA1 antibody at 20 µg/mL.

NP_001154; 22035548

92865

APBA1; At least two alternatively spliced isoforms are known to exist; this antibody will detect both isoforms. This antibody is predicted to not cross-react with other APBA proteins.

APBA1 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

APBA1 antibody can be used for detection of APBA1 by Western blot at 0.5 µg/mL. For immunofluorescence start at 20 µg/mL.

APBA1 Antibody is supplied in PBS containing 0.02% sodium azide.