ArtNr |
ABC-ASC11247 |
Hersteller |
Abcepta
|
Menge |
100 ug |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, IF, ELISA, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Lieferbar |
|
Primary Accession |
Q13433 |
Application |
WB, IHC-P, IF, E |
Bio Background |
ZIP6 Antibody: The zinc transporter ZIP6, also known as SLC39A6, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP6 expression has also been reported in human cervical cancer and the HeLa cell line; down-regulation of ZIP6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP6 plays a regulatory role on the ERK1/2-Snail/Slug pathway. |
Bio References |
Dufner-Beattie J, Langmade SJ, Wang F, et al. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. J. Biol. Chem.2003; 278:50142-50. Eide DJ. The SLC39 family of metal ion transporters. Pflugers Arch.2004; 447:796-800.Taylor KM and Nicohlson RI. The LZT proteins; the LIV-1 subfamily of zinc transporters. Biochim. Biophys. Acta.2003; 1611:16-30. Taylor KM. LIV-1 breast cancer protein belongs to new family of histidine-rich membrane proteins with potential to control intracellular ZN2+ homeostasis. IUBMB Life2000; 49:249-53. |
Clonality |
Polyclonal |
Gene ID |
25800 |
Gene Name |
SLC39A6 |
Reactivity |
H, M |
Legend image 1 |
Western blot analysis of ZIP6 in mouse lung tissue lysate with ZIP6 antibody at 1 µg/mL. |
Type image 1 |
WB |
Legend image 2 |
Immunohistochemistry of ZIP6 in mouse lung tissue with ZIP6 antibody at 5 µg/mL. |
Type image 2 |
IHC |
Legend image 3 |
Immunofluorescence of ZIP6 in mouse lung tissue with ZIP6 antibody at 20 µg/mL. |
Type image 3 |
IF |
Other Accession |
NP_001092876; 153252214 |
Isotype |
IgG |
Calculated MW |
85047 |
Antigen Source |
Homo sapiens |
Target/Specificity |
SLC39A6; |
Purification |
ZIP6 Antibody is affinity chromatography purified via peptide column. |
Reconstitution & Storage |
ZIP6 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Antibody Form |
Liquid |
Application Notes |
ZIP6 antibody can be used for detection of ZIP6 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 µg/mL. For immunofluorescence start at 20 µg/mL. |
Positive Control |
Mouse Lung Tissue Lysate; |
Buffer |
ZIP6 Antibody is supplied in PBS containing 0.02% sodium azide. |
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