« Zurück
Home /
BCAS3 Antibody

BCAS3 Antibody

ArtNr	ABC-ASC11077
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Primary Accession	Q9H6U6
Application	WB, IHC-P, IF, E
Bio Background	BCAS3 Antibody: The Breast carcinoma amplified sequence (BCAS3) gene is localized to 17q23, a region that is often amplified in breast cancers. Copy number gains at this region have also been reported in other tumors such as brain, lung, liver, testis and bladder. BCAS3 is thought to be an estrogen receptor (ER)-alpha co-activator that acts through PELP1, another ER-alpha that in turn activates BCAS3 expression. This may set up a positive feedback loop leading to ER-a signal amplification in the cell which may play a significant role in breast cancer. BCAS3 expression has also been observed in embryonic stem cells and vascular precursors, suggesting that it may also play a role in embryogenesis and tumor angiogenesis.
Bio References	Barlund M, Monni O, Weaver JD, et al. Cloning of BCAS3 (17q23) and BCAS4 (20q13) genes that undergo amplification, overexpression, and fusion in breast cancer. Genes Chromosomes Cancer2002; 35:311-7. Sinclair CS, Rowley M, Naderi A, et al. The 17q23 amplicon and breast cancer. Breast Cancer Res. Treat.2003; 78:313-22. Gururaj AE, Peng S, Vadlamudi RK, et al. Estrogen induces expression of BCAS3, a novel estrogen receptor-a coactivator, through Proline-, Glutamic acid-, and leucine-rich protein -1 (PELP1). Mol. Endocrinol.2007; 21:1847-60. Siva K, Venu P, Mahadevan A, et al. Human BCAS3 expression in embryonic stem cells and vascular precursors suggests a role, in human ebryogenesis and tumor angiogenesis. PloS One2007; 11:e1202.
Clonality	Polyclonal
Gene ID	54828
Gene Name	BCAS3 {ECO:0000312\|HGNC:HGNC:14347, ECO:0000312\|MIM:607470}
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of BCAS3 in rat brain tissue lysate with BCAS3 antibody at (A) 0.5 and (B) 1 µg/mL.
Type image 1	WB
Legend image 2	Immunohistochemistry of BCAS3 in human breast carcinoma with BCAS3 antibody at 5 µg/mL.
Type image 2	IHC
Legend image 3	Immunofluorescence of BCAS3 in human breast carcinoma tissue with BCAS3 antibody at 20 µg/mL.
Type image 3	IF
Other Accession	EAW51415; 119571800
Isotype	IgG
Calculated MW	101237
Antigen Source	Homo sapiens
Target/Specificity	BCAS3;
Purification	BCAS3 Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	BCAS3 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody Form	Liquid
Application Notes	BCAS3 antibody can be used for detection of BCAS3 by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	Rat Brain Tissue Lysate;
Buffer	BCAS3 Antibody is supplied in PBS containing 0.02% sodium azide.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

ABC-ASC11077-datasheet.pdf

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 100 ug

lieferbar

Lieferung vsl. bis 08.11.2024

Express-Lieferung: 31 Tage sparen

Vergleichen

Auf den Wunschzettel

Weiterempfehlen per Mail