ArtNr |
ABC-ASC10861 |
Hersteller |
Abcepta
|
Menge |
100 ug |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, IF, ELISA, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Lieferbar |
|
Primary Accession |
Q791V5 |
Application |
WB, IHC-P, IF, E |
Bio Background |
MTCH2 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals, suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway. |
Bio References |
Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ.2000; 7:2-7.Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene2003; 22:8590-607.Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron.2004; 39:1125-35.Grinberg M, Schwarz M, Zaltsman Y, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol.2005; 25:4579-90. |
Clonality |
Polyclonal |
Gene ID |
56428 |
Gene Name |
Mtch2 |
Reactivity |
H, M |
Legend image 1 |
Western blot analysis of MTCH2 in 293 cell lysate with MTCH2 antibody at 1 µg/mL. |
Type image 1 |
WB |
Legend image 2 |
Immunohistochemistry of MTCH2 in mouse kidney tissue with MTCH2 antibody at 5 µg/mL. |
Type image 2 |
IHC |
Legend image 3 |
Immunofluorescence of MTCH2 in Mouse Kidney cells with MTCH2 antibody at 20 µg/mL. |
Type image 3 |
IF |
Other Accession |
NP_055157; 5815347 |
Isotype |
IgG |
Calculated MW |
33499 |
Antigen Source |
Mus musculus |
Target/Specificity |
Mtch2; |
Purification |
MTCH2 Antibody is affinity chromatography purified via peptide column. |
Reconstitution & Storage |
MTCH2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Antibody Form |
Liquid |
Application Notes |
MTCH2 antibody can be used for detection of MTCH2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL. |
Positive Control |
293 Cell Lysate; |
Buffer |
MTCH2 Antibody is supplied in PBS containing 0.02% sodium azide. |
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