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MTCH2 Antibody

ArtNr ABC-ASC10861
Hersteller Abcepta
Menge 100 ug
Kategorie
Typ Antibody Primary
Applikationen WB, IF, ELISA, IHC-P
Specific against other
Host Rabbit
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Lieferbar
Primary Accession
Q791V5
Application
WB, IHC-P, IF, E
Bio Background
MTCH2 Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death. MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals, suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway.
Bio References
Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ.2000; 7:2-7.
Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene2003; 22:8590-607.
Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron.2004; 39:1125-35.
Grinberg M, Schwarz M, Zaltsman Y, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol.2005; 25:4579-90.
Clonality
Polyclonal
Gene ID
56428
Gene Name
Mtch2
Reactivity
H, M
Legend image 1
Western blot analysis of MTCH2 in 293 cell lysate with MTCH2 antibody at 1 µg/mL.
Type image 1
WB
Legend image 2
Immunohistochemistry of MTCH2 in mouse kidney tissue with MTCH2 antibody at 5 µg/mL.
Type image 2
IHC
Legend image 3
Immunofluorescence of MTCH2 in Mouse Kidney cells with MTCH2 antibody at 20 µg/mL.
Type image 3
IF
Other Accession
NP_055157; 5815347
Isotype
IgG
Calculated MW
33499
Antigen Source
Mus musculus
Target/Specificity
Mtch2;
Purification
MTCH2 Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage
MTCH2 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody Form
Liquid
Application Notes
MTCH2 antibody can be used for detection of MTCH2 by Western blot at 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control
293 Cell Lysate;
Buffer
MTCH2 Antibody is supplied in PBS containing 0.02% sodium azide.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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