ArtNr |
ABC-ASC10091 |
Hersteller |
Abcepta
|
Menge |
100 ug |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, IF, ICC, ELISA, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
EPR-1, Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor 4, API4, IAP4, Survivin Antibody: API4, baculoviral IAP repeat-containing 5 |
Lieferbar |
|
Primary Accession |
O15392 |
Application |
WB, IHC-P, IF, ICC, E |
Bio Background |
Survivin Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP. Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas. |
Bio References |
Ambrosini G, Adida C, and Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 1997; 3:917-21.Li F, Ambrosini G, Chu EY, et al. Control of apoptosis and mitotic spindle checkpoint by survivin. Nature 1998; 396:580-4.Kobayashi K, Hatano M, Otaki M, et al. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation. Proc. Natl. Acad. Sci. USA 1999; 96:1457-62. |
Clonality |
Polyclonal |
Gene ID |
332 |
Gene Name |
BIRC5 |
Reactivity |
H, M |
Legend image 1 |
Immunohistochemistry of Adiponectin in mouse brain tissue with Adiponectin antibody at 5 µg/ml. |
Type image 1 |
IHC |
Legend image 2 |
Immunohistochemistry of XIAP in mouse kidney tissue with XIAP antibody at 5 µg/mL. |
Type image 2 |
IHC |
Other Accession |
NP_001159; 332 |
Isotype |
IgG |
Calculated MW |
16389 |
Antigen Source |
Homo sapiens |
Target/Specificity |
Survivin antibody was raised against a peptide corresponding to 12 amino acids near the amino terminus of human survivin.
The immunogen is located within the first 50 amino acids of Survivin. |
Purification |
Survivin Antibody is affinity chromatography purified via peptide column. |
Reconstitution & Storage |
Survivin antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Antibody Form |
Liquid |
Application Notes |
Survivin antibody can be used for detection of survivin by Western blot at 1 - 2 μ g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ g/mL and immunocytochemistry starting at 5 μ g/mL. For immunofluorescence start at 20 μ g/mL. |
Positive Control |
MOLT4 Cell Lysate; Jurkat Cell Lysate |
Buffer |
Survivin Antibody is supplied in PBS containing 0.02% sodium azide. |
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