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C5 Antibody (N-term)

C5 Antibody (N-term)

ArtNr	ABC-AP8577a-ev
Hersteller	Abcepta
Menge	80 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, FC, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Complement C5, C5, C5a anaphylatoxin, CPAMD4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5 alpha chain, Complement C5 beta chain, Complement C5 alpha' chain
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Primary Accession	P01031
Antigen Type	Synthetic Peptide
Application	FC, IHC-P, WB
Bio Background	C5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.
Bio References	McClure, A., et.al., Rheumatology (Oxford) 48 (11), 1369-1374 (2009) DiScipio, R.G.et.al., J. Biol. Chem. 267 (24), 17087-17094 (1992)
Clonality	Polyclonal
Clone/Animal Names	RB21866
Gene ID	727
Gene Name	C5
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of C5 Antibody (N-term) (Cat. #AP8577a) in HL-60 cell line lysates (35ug/lane). C5 (arrow) was detected using the purified Pab.(2ug/ml)
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human breast carcinoma with C5 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:50~100
Legend image 3	Flow cytometric analysis of MDA-231 cells using C5 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 3	FC
Dilution image 3	1:10~50
Isotype	Rabbit IgG
Calculated MW	188305
Antigen Region	253-281
Antigen Source	HUMAN
Target/Specificity	This C5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-281 amino acids of human C5.
NCBI Accession	NP_001726.2

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ABC-AP8577a-ev-datasheet.pdf

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Menge: 80 ul

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