ArtNr |
ABC-AP7960e-ev |
Hersteller |
Abcepta
|
Menge |
80 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
MAP2K1, MEK1, Dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAPK/ERK kinase 1, PRKMK1, MKK1, MAP kinase kinase 1, MAPKK 1, MEK 1 |
Lieferbar |
|
Primary Accession |
Q02750 |
Antigen Type |
Synthetic Peptide |
Application |
WB, IHC-P |
Bio Background |
MAP2K1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. |
Bio References |
Zheng, B., et al., Blood 102(3):1019-1027 (2003).Li, S.P., et al., Cancer Res. 63(13):3473-3477 (2003).Zhu, X., et al., J. Neurochem. 86(1):136-142 (2003).Fringer, J., et al., J. Biol. Chem. 278(23):20612-20617 (2003).Witowsky, J.A., et al., J. Biol. Chem. 278(3):1403-1406 (2003). |
Clonality |
Polyclonal |
Clone/Animal Names |
RB11151 |
Gene ID |
5604 |
Gene Name |
|
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
MAP2K1 Antibody (pT291) (Cat.# AP7960e) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the MAP2K1 antibody detected the MAP2K1 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with MAP2K1 Antibody (T291) (Cat.#AP7960e), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. |
Type image 2 |
IHC-P |
Dilution image 2 |
1:10~50 |
Other Accession |
Q01986; P29678; P31938; Q63980 |
Predicted |
Ha, M, Rb, Rat |
Isotype |
Rabbit Ig |
Calculated MW |
43439 |
Antigen Region |
270-299 |
Antigen Source |
HUMAN |
Target/Specificity |
This MAP2K1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 270-299 amino acids from human MAP2K1. |
NCBI Accession |
NP_002746.1 |
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