ArtNr |
ABC-AP7788c-ev-50ul |
Hersteller |
Abcepta
|
Menge |
50 ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Applikationen |
Western Blot, Flow cytometry, Immunohistochemistry |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Cytochrome P450 3A4, 11413-,8-cineole 2-exo-monooxygenase, Albendazole monooxygenase, Albendazole sulfoxidase, CYPIIIA3, CYPIIIA4, Cytochrome P450 3A3, Cytochrome P450 HLp, Cytochrome P450 NF-25, Cytochrome P450-PCN1, Nifedipine oxidase, Quinine 3-monooxy |
Lieferbar |
|
Primary Accession |
P08684 |
Antigen Type |
Synthetic Peptide |
Bio Background |
CYP3A4, is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. |
Bio References |
Sandanaraj, E., Clin. Cancer Res. 14 (21), 7116-7126 (2008) Nelson, D.R., Pharmacogenetics 14 (1), 1-18 (2004) Inoue, K., Jpn. J. Hum. Genet. 37 (2), 133-138 (1992) |
Gene ID |
1576 |
Gene Name |
CYP3A4 {ECO:0000303|PubMed:11470997, ECO:0000312|HGNC:HGNC:2637} |
Reactivity |
H |
Calculated MW |
57343 |
Antigen Region |
228-255 |
Antigen Source |
HUMAN |
Target/Specificity |
This CYP3A4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-255 amino acids from the Central region of human CYP3A4. |
NCBI Accession |
NP_001189784.1; NP_059488.2 |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.