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BACE Antibody (S498)

BACE Antibody (S498)

Hersteller	Abcepta
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Specific against	other
Isotype	Ig
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB
Menge	400 ul
Host	Rabbit
ArtNr	ABC-AP7774a
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Primary Accession	P56817
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is BACE. This protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi.
Bio References	Xie, J., et al., J. Biol. Chem. 280(14):13824-13832 (2005). He, X., et al., J. Biol. Chem. 280(12):11696-11703 (2005). Huang, X.P., et al., J. Biol. Chem. 279(36):37886-37894 (2004). Chiocco, M.J., et al., J. Biol. Chem. 279(50):52535-52542 (2004). Yang, H.C., et al., J. Neurochem. 91(6):1249-1259 (2004).
Clonality	Polyclonal
Clone/Animal Names	RB7137
Gene ID	23621
Gene Name	BACE1 (HGNC:933)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	Western blot analysis of anti-BACE Antibody (S498) (Cat.#AP7774a) in mouse cerebellum tissue lysates (35ug/lane). BACE (arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	All lanes : Anti-Phospho-BACE(S498) Antibody, ctrl at 1:1000 dilution Lane 1: SH-SY5Y whole cell lysate Lane 2: U-251 MG whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 56 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 2	WB
Dilution image 2	1:1000
Other Accession	P56819; P56818; Q2HJ40
Predicted	B, Rat
Isotype	Rabbit Ig
Calculated MW	55764
Antigen Region	476-501
Antigen Source	HUMAN
Target/Specificity	This BACE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 476-501 amino acids from human BACE.
NCBI Accession	NP_001193978.1; NP_036236.1; NP_620427.1; NP_620428.1; NP_620429.1

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ABC-AP7774a-datasheet.pdf

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Menge: 400 ul

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Lieferung vsl. bis 06.09.2024

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