ArtNr |
ABC-AP7660B |
Hersteller |
Abcepta
|
Menge |
400 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Applikationen |
WB, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
DDR1, CD167a, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE, Epithelial discoidin domain-containing receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, Protein-tyrosine kinase 3A, Epithelial discoidin domain receptor 1, TRK E, Tyrosine kinase DDR, MCK-10, Tyrosine-protein kinase CAK, Protein-tyrosine kinase RTK-6 |
Lieferbar |
|
Primary Accession |
Q08345 |
Antigen Type |
Synthetic Peptide |
Application |
WB, IHC-P |
Bio Background |
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. The gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. |
Bio References |
Vogel, W., et al., Mol. Cell 1(1):13-23 (1997).Playford, M.P., et al., Genome Res. 6(7):620-627 (1996).Perez, J.L., et al., Oncogene 12(7):1469-1477 (1996).Valent, A., et al., Hum. Genet. 98(1):12-15 (1996).Edelhoff, S., et al., Genomics 25(1):309-311 (1995). |
Clonality |
Polyclonal |
Clone/Animal Names |
RB1480 |
Gene ID |
780 |
Gene Name |
DDR1 |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, M |
Legend image 1 |
Western blot analysis of anti-MCK10 Pab (Cat. #AP7660a) in mouse lung lysate. MCK10 (Arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
Western blot analysis of DDR1 (arrow) using MCK10 Antibody (C-term) (Cat.#AP7660b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DDR1 gene (Lane 2) (Origene Technologies). |
Type image 2 |
WB |
Dilution image 2 |
1:1000 |
Legend image 3 |
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. |
Type image 3 |
IHC-P |
Dilution image 3 |
1:50~100 |
Isotype |
Rabbit Ig |
Calculated MW |
101128 |
Antigen Region |
873-904 |
Antigen Source |
HUMAN |
Target/Specificity |
This DDR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 873-904 amino acids from the C-terminal region of human DDR1. |
NCBI Accession |
NP_001189450.1; NP_001189451.1; NP_001189452.1; NP_001945.3; NP_054699.2; NP_054700.2 |
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