Alias |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A, Dual specificity YAK1-related kinase, HP86, Protein kinase minibrain homolog, MNBH, hMNB, DYRK1A, DYRK, MNB, MNBH |
Bio Background |
DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. |
Bio References |
Adayev, T., Biochemistry 46 (25), 7614-7624 (2007) Chang, H.S., Int. J. Cancer 120 (11), 2377-2385 (2007) Alvarez, M., Mol. Biol. Cell 18 (4), 1167-1178 (2007) Wissing, J., Mol. Cell Proteomics 6 (3), 537-547 (2007) |