Alias |
Aurora kinase B, Aurora 1, Aurora- and IPL1-like midbody-associated protein 1, AIM-1, Aurora/IPL1-related kinase 2, ARK-2, Aurora-related kinase 2, STK-1, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5, Serine/threonine-protein kina |
Bio Background |
Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. STK12 (Aurora kinase B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A localizes to centrosomes |
Bio References |
Kimura, M., et al., Biochem. Biophys. Res. Commun. 316(3):930-936 (2004). Yasui, Y., et al., J. Biol. Chem. 279(13):12997-13003 (2004). Lampson, M.A., et al., Nat. Cell Biol. 6(3):232-237 (2004). Wheatley, S.P., et al., J. Biol. Chem. 279(7):5655-5660 (2004). Honda, R., et al., Mol. Biol. Cell 14(8):3325-3341 (2003). |