ILK2/ILK1 Antibody (C-term)

Synthetic Peptide

Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK) is an ankyrin repeat containing 51 kDa receptor-proximate serine-threonine kinase (1), with a reported migration rate of 59K. This 451 amino acid protein interacts with the cytoplasmic domain of the beta-1 integrin subunit and contains sequence motifs found in pleckstrin homology domains capable of interacting with phosphoinositide lipids. ILK is an upstream regulator of Pi(3)K dependant activation of protein kinase B (PKB/AKT) and inhibition of glycogen synthase kinase 3 (GSK-3). ILK2 expression is associated with mediation of cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. ILK2 is overexpressed in some highly invasive tumor cell lines.

RB5343

ILK (HGNC:6040)

H, M

WB

Western blot analysis of anti-ILK2/ILK1 Antibody (C-term) (Cat.#AP7077b) in mouse heart tissue lysates (35ug/lane). ILK2(arrow) was detected using the purified Pab.

1:1000

B, Rat

51419

HUMAN

NP_001014794.1; NP_001014795.1; NP_001265370.1; NP_004508.1