ArtNr |
ABC-AP5564a-ev |
Hersteller |
Abcepta
|
Menge |
80 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB, FC, IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
RANBP9, IPO9, Imp9, Importin-9, Ran-binding protein 9, RanBP9, KIAA1192, IMP9 |
Lieferbar |
|
Primary Accession |
Q96P70 |
Antigen Type |
Synthetic Peptide |
Application |
FC, IHC-P, WB |
Bio Background |
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of H2B histone (By similarity), RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones (By similarity), RPL4 and RPL6. |
Bio References |
King, F.W., et al. Mol. Cell. Biol. 24(16):7091-7101(2004)Lubert, E.J., et al. Biochem. Biophys. Res. Commun. 303(3):908-913(2003)Jakel, S., et al. EMBO J. 21(3):377-386(2002)Muhlhausser, P., et al. EMBO Rep. 2(8):690-696(2001) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB26877 |
Gene ID |
55705 |
Gene Name |
IPO9 |
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H, M |
Legend image 1 |
IPO9 Antibody (N-term) (Cat. #AP5564a) western blot analysis in mouse Neuro-2a cell line lysates (15ug/lane).This demonstrates the IPO9 antibody detected the IPO9 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
IPO9 Antibody (N-term) (Cat. #AP5564a) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IPO9 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
Type image 2 |
IHC-P |
Dilution image 2 |
1:50~100 |
Legend image 3 |
IPO9 Antibody (N-term) (Cat. #AP5564a) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Type image 3 |
FC |
Dilution image 3 |
1:10~50 |
Other Accession |
Q91YE6; NP_060555.2 |
Isotype |
Rabbit Ig |
Calculated MW |
115963 |
Antigen Region |
79-106 |
Antigen Source |
HUMAN |
Target/Specificity |
This IPO9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-106 amino acids from the N-terminal region of human IPO9. |
NCBI Accession |
NP_060555.2 |
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