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GLP1 Antibody (Center)

GLP1 Antibody (Center)

ArtNr	ABC-AP5500c
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB, FC
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	GLP-1, GLP1, ZGLP1, GATA-type zinc finger protein 1, GATA-like protein 1
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Primary Accession	P0C6A0
Antigen Type	Synthetic Peptide
Application	FC, WB
Bio Background	Glucagon is initially synthesised as proglucagon, which is 180 amino acids in length and is cleaved proteolytically. It contains a region corresponding to Glucagon itself, in addition to a signal peptide, spacer regions and two Glucagon-like peptide sequences. GLP1 is encoded by the fourth exon of the six in the human Glucagon gene. It is 37 amino acids in length and has 48% amino acid sequence homology to Glucagon, and is thought to have arisen by gene duplication. The sequence of GLP1 is conserved across many species, however, indicating that it has a particular function. GLP1 is a potent insulin secretagogue, renders pancreatic beta cells 'glucose-competent' and may be useful in the treatment of diabetes mellitus.
Bio References	Sanz, C., et al. Am. J. Physiol. Endocrinol. Metab. 298 (3), E634-E643 (2010) : Brown, R.J., et al. Diabetes Care 32(12):2184-2186(2009) Li, S., et al. Dev. Biol. 301(1):106-116(2007)
Clonality	Polyclonal
Clone/Animal Names	RB26991
Gene ID	100125288
Gene Name	ZGLP1 (HGNC:37245)
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	GLP1 Antibody (Center) (Cat.#AP5500c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GLP1 antibody detected the GLP1 protein (arrow).
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	GLP1 Antibody (Center) (Cat. #AP5500c) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Type image 2	FC
Dilution image 2	1:10~50
Other Accession	NP_001096637.1
Isotype	Rabbit Ig
Calculated MW	29628
Antigen Region	85-112
Antigen Source	HUMAN
Target/Specificity	This GLP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the Central region of human GLP1.
NCBI Accession	NP_001096637.1

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Menge: 400 ul

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