ArtNr |
ABC-AP5500c |
Hersteller |
Abcepta
|
Menge |
400 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB, FC |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
GLP-1, GLP1, ZGLP1, GATA-type zinc finger protein 1, GATA-like protein 1 |
Lieferbar |
|
Primary Accession |
P0C6A0 |
Antigen Type |
Synthetic Peptide |
Application |
FC, WB |
Bio Background |
Glucagon is initially synthesised as proglucagon, which is 180 amino acids in length and is cleaved proteolytically. It contains a region corresponding to Glucagon itself, in addition to a signal peptide, spacer regions and two Glucagon-like peptide sequences. GLP1 is encoded by the fourth exon of the six in the human Glucagon gene. It is 37 amino acids in length and has 48% amino acid sequence homology to Glucagon, and is thought to have arisen by gene duplication. The sequence of GLP1 is conserved across many species, however, indicating that it has a particular function. GLP1 is a potent insulin secretagogue, renders pancreatic beta cells 'glucose-competent' and may be useful in the treatment of diabetes mellitus. |
Bio References |
Sanz, C., et al. Am. J. Physiol. Endocrinol. Metab. 298 (3), E634-E643 (2010) :Brown, R.J., et al. Diabetes Care 32(12):2184-2186(2009)Li, S., et al. Dev. Biol. 301(1):106-116(2007) |
Clonality |
Polyclonal |
Clone/Animal Names |
RB26991 |
Gene ID |
100125288 |
Gene Name |
|
Subtitle |
Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
GLP1 Antibody (Center) (Cat.#AP5500c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the GLP1 antibody detected the GLP1 protein (arrow). |
Type image 1 |
WB |
Dilution image 1 |
1:1000 |
Legend image 2 |
GLP1 Antibody (Center) (Cat. #AP5500c) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
Type image 2 |
FC |
Dilution image 2 |
1:10~50 |
Other Accession |
NP_001096637.1 |
Isotype |
Rabbit Ig |
Calculated MW |
29628 |
Antigen Region |
85-112 |
Antigen Source |
HUMAN |
Target/Specificity |
This GLP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the Central region of human GLP1. |
NCBI Accession |
NP_001096637.1 |
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