Bio Background |
This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. |
Bio References |
Tang, X.H., et al. Exp. Cell Res. 314(1):38-51(2008) Uhrig, M., et al. BMC Med 6, 38 (2008) : Guidez, F., et al. Proc. Natl. Acad. Sci. U.S.A. 104(47):18694-18699(2007) Tanaka, K., et al. Oncogene 26(44):6456-6468(2007) Wu, Q., et al. Mol. Cancer 6, 45 (2007) : Flagiello, D., et al. Cytogenet. Cell Genet. 76 (1-2), 17-18 (1997) : Liu, W., et al. Biochem. Biophys. Res. Commun. 229(3):922-929(1996) Eller, M.S., et al. Exp. Cell Res. 198(2):328-336(1992) Astrom, A., et al. J. Biol. Chem. 266(26):17662-17666(1991) Ong, D.E. Arch Dermatol 123 (12), 1693-1695A (1987) : |