Vergleich

CD31 Antibody

Hersteller Abcepta
Kategorie
Typ Antibody Primary
Specific against other
Applikationen WB, IP
Menge 100 ul
Host Mouse
ArtNr ABC-AP52799
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Primary Accession
P16284
Antigen Type
Recombinant Protein
Application
WB, IP
Bio Background
Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
Bio References
Simmons D.L., et al.J. Exp. Med. 171:2147-2152(1990).
Stockinger H., et al.J. Immunol. 145:3889-3897(1990).
Newman P.J., et al.Science 247:1219-1222(1990).
Albelda S.M., et al.J. Cell Biol. 114:1059-1068(1991).
Kirschbaum N.E., et al.Blood 84:4028-4037(1994).
Clonality
Monoclonal
Gene ID
5175
Gene Name
PECAM1
Subtitle
Purified Mouse Monoclonal Antibody (Mab)
Reactivity
H
Legend image 1
Immunoprecipitation analysis of THP-1 cell lysates using CD31 mouse mAb.
Type image 1
IP
Dilution image 1
1:500
Legend image 2
Western blot detection of CD31 in THP-1 cell lysate using CD31 mouse mAb (1:1000 diluted).Predicted band size: 130KDa.Observed band size: 130KDa.
Type image 2
WB
Dilution image 2
1:1000

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ul
Lieferbar: In stock
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