ArtNr |
ABC-AP3916a |
Hersteller |
Abcepta
|
Menge |
200 ul |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Applikationen |
WB |
Specific against |
other |
Host |
Rabbit |
Isotype |
Ig |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
EEF2K, Eukaryotic elongation factor 2 kinase, Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase, eEF-2K, eEF-2 kinase, 2.7.11.20 |
Lieferbar |
|
Primary Accession |
O00418 |
Antigen Type |
Synthesized Peptide |
Application |
WB |
Bio Background |
Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. |
Bio References |
Ryazanov A.G., et al.Proc. Natl. Acad. Sci. U.S.A. 94:4884-4889(1997).Martin J., et al.Nature 432:988-994(2004).Pavur K.S., et al.Biochemistry 39:12216-12224(2000).Knebel A., et al.EMBO J. 20:4360-4369(2001).Wang X., et al.EMBO J. 20:4370-4379(2001). |
Clonality |
polyclonal |
Clone/Animal Names |
RB56631 |
Gene ID |
29904 |
Gene Name |
EEF2K |
Subtitle |
Purified Rabbit Polyclonal Antibody (Pab) |
Reactivity |
H |
Legend image 1 |
Western blot analysis of lysates from Hela cell line, untreated or treated with TPA, 200nM, using (Cat. #AP3916a)(upper) or Beta-actin (lower). |
Type image 1 |
WB |
Dilution image 1 |
1:500 |
Isotype |
Rabbit Ig |
Calculated MW |
82144 |
Antigen Source |
HUMAN |
Target/Specificity |
This Phospho-eEF2k (Ser366) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 337-371 amino acids from the human region of human EEF2k. |
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