Bio Background |
Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. |
Bio References |
Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009) Haraguchi, T., et al. Fertil. Steril. 91 (4 SUPPL), 1424-1426 (2009) : De Martino, I., et al. Cancer Res. 69(5):1844-1850(2009) Bellanger, S., et al. Oncogene 26(51):7175-7184(2007) Stav, D., et al. Int. J. Biol. Markers 22(2):108-113(2007) |