Phospho-PTEN(Y240) Antibody

Synthetic Peptide

This gene was identified as a tumor suppressor that is
mutated in a large number of cancers at high frequency. The protein
encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate
3-phosphatase. It contains a tensin like domain as well as a
catalytic domain similar to that of the dual specificity protein
tyrosine phosphatases. Unlike most of the protein tyrosine
phosphatases, this protein preferentially dephosphorylates
phosphoinositide substrates. It negatively regulates intracellular
levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and
functions as a tumor suppressor by negatively regulating AKT/PKB
signaling pathway.

Polyclonal

5728

Affinity Purified Rabbit Polyclonal Antibody (Pab)

Dot blot analysis of Phospho-PTEN-Y240 Antibody Phospho-specific Pab (Cat. #AP3788i) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

1:500

M

47166

This PTEN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y240 of human PTEN.