Vergleich

Phospho-PTEN(T383) Antibody

ArtNr ABC-AP3788f-ev-80ul
Hersteller Abcepta
Menge 80 ul
Kategorie
Typ Antibody Polyclonal
Applikationen Dot blot
Specific against other
Host Rabbit
Isotype Ig
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Phosphatidylinositol 3,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1
Lieferbar
Primary Accession
P60484
Other Accession
Q9PUT6; O08586; NP_000305.3
Antigen Type
Synthetic Peptide
Bio Background
This gene was identified as a tumor suppressor that is
mutated in a large number of cancers at high frequency. The protein
encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate
3-phosphatase. It contains a tensin like domain as well as a
catalytic domain similar to that of the dual specificity protein
tyrosine phosphatases. Unlike most of the protein tyrosine
phosphatases, this protein preferentially dephosphorylates
phosphoinositide substrates. It negatively regulates intracellular
levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and
functions as a tumor suppressor by negatively regulating AKT/PKB
signaling pathway.
Bio References
Miletic, A.V., et al. J. Exp. Med. 207(11):2407-2420(2010)
Kini, V., et al. J. Biol. Chem. 285(43):33082-33091(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Molina, J.R., et al. Cancer Res. 70(17):6697-6703(2010)
Iliopoulos, D., et al. Mol. Cell 39(4):493-506(2010)
Gene ID
5728
Gene Name
PTEN
Reactivity
H
Predicted
M, X
Calculated MW
47166
Antigen Source
HUMAN
Target/Specificity
This PTEN Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T383 of human PTEN.
NCBI Accession
NP_000305.3

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Menge: 80 ul
Lieferbar: Out of stock
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