Phospho-IKKB(S697) Antibody

NP_001177649.1

NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL
(MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the
NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins
(NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate
NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of
serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM
600664, or IKBKB) marks them for destruction via the ubiquitination
pathway, thereby allowing activation of the NF-kappa-B complex.
Activated NFKB complex translocates into the nucleus and binds DNA
at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or
5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G
purine; and Y is a C or T pyrimidine).

3551

H

HUMAN

NP_001177649.1; NP_001229707.1; NP_001547.1